I have posted a long description of and historical rationale behind Cell Signaling Factors (CSF’s) on www.cheneyinsitute.com using the Cell Signaling Factors link button on this web site. We now have available Bison Heart Cell Signaling Factors which historically has been demonstrated to be the most powerful of all the transdermal CSF’s by IVRT response criteria on the echocardiograph machine in terms of improving cellular and mitochondrial energy production in real time. I suspect this is because the Bison Heart consumes more oxygen per pound than any other land mammal with a trachea diameter of four inches which allows it’s 2,000 pound body to consume oxygen at a prodigious rate to run across the hot prairie at 30 mph all day long. This prodigious use of oxygen implies an equally prodigious ability to metabolize oxygen metabolites such as superoxide produced by such a high level of aerobic energy production.
My guess is that the small peptides in Bison Heart act by binding to G-protein coupled receptors (GPCR’s) which have flanking receptors for very small peptides which activate the GPCR (see https://en.wikipedia.org/wiki/G_protein–coupled_receptor). Note that eight Nobel Prizes have been awarded to researchers in either the field of GPCR’s or the many metabolic pathways they regulate. The exact number of GPCR’s is unknown but over 800 genes are suspected of coding for these GPCR’s. Pay special attention to the list of physiologic roles for GPCR’s listed in the Wikipedia link. I strongly suspect that Bison Heart CSF’s up-regulate the enzymes SOD and GPx which are the key enzymes controlling the ability of the cell to control excess superoxide, a dangerous by-product of high aerobic energy production. If true then the combination of Bison Heart CSF’s in the daytime along with anabolic support via both MTF and Porcine Liver at bedtime which support NADPH and GSG/GSSG will be the best combination to support the otherwise impaired redox buffer state at the core of CFS.
If you are interested in Bison Heart CSF’s, please call or email Dixie to order it. The dose is two – four drops to the forearm on arising every day. Porcine Heart CSF’s are now discontinued in favor of Bison Heart which is much stronger in terms of aerobic energy production support. Note that MTF is basically stem cell peptides derived from porcine placenta and acts similar to stem cells which supports anabolism though it disfavors catabolism (aka ATP production) and Porcine Liver supports NADPH production which supports detoxification, peroxisomal function, GSH/GSSG and also inhibits HHV-6A via its similarity to Kutapressin. MTF is very potent and will cause energy collapse if used at higher doses (aka applied to the forearm or neck as opposed to the top of the foot) or too frequently.